WHAT WE DISCOVERED
A compact view of the laboratory's scientific trajectory—from gene regulation to the behaviour of the tumour cell and its ecosystem.
Follow the
evidence.
A compact view of the laboratory's scientific trajectory—from gene regulation to the behaviour of the tumour cell and its ecosystem.
Why GM2-synthase rises.
Our work has investigated transcriptional and chromatin mechanisms underlying B4GALNT1/GM2-synthase deregulation in cancer.
GM2 becomes a signalling cue.
GM2-associated membrane signalling engages integrin-linked pathways and the FAK/Src-ERK axis, connecting lipid abundance to malignant cell behaviour.
A lipid can change phenotype.
GM2-driven signalling is linked with EMT, migration, invasion and anchorage-independent growth, providing a mechanistic bridge to metastatic competence.
One lipid. Multiple scales of biology.
Follow the laboratory's central mechanistic thread from gene regulation to tumour-cell signalling, microenvironmental remodelling and metastatic growth.
+ SIGNAL
→ ERK / EGR1
· INVASION
→ TME / CAF
GROWTH